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During the development of kidney stones, risk factors such as CaOx crystals, urine microenvironmental changes, and selenium deficiency induce ferroptosis through mechanisms such as oxidative stress, ERS, and autophagy

These changes included heightened levels of GABA and other defense molecules, correlating with the initiation of plant defense responses (OLeary et al

Declaration of Interest SJ has no conflicts of interest to declare

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However, the fact that AOXs are largely available over-the-counter with a reasonable price increases the risk that some patients can overmedicate with AOXs leading to detrimental effects

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