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PS linkages enhance aptamer stability and binding affinity, making them ideal for pancreatic cancer (144), brain tumors due to their ability to cross the blood brain barrier (140), also melanoma since phosphorotioated aptamer have special anti-melanoma effect (110)

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This happened through the inferior anterior pancreaticoduodenal vein to superior mesenteric vein flow, which is an effect related to the NO system and reduction of free radical formation

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In addition, in research on aging-related muscle atrophy (sarcopenia), it can promote muscle cell proliferation and differentiation, reduce muscle cell apoptosis, and enhance muscle strength and endurance by activating the SIRT1 signaling pathway