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Walls become thin, cavities large the typical eccentric remodeling process

A particular relationship was established with the NO-system, and the advantage of the BPC 157 over the corresponding standard agents (i.e., corticosteroids, sulfasalazine, H2 blockers, anticholinergics, and proton pump inhibitors) which showed only weak, if any, effect on these fistulas closing (Klicek et al., 2008

however, caution is still necessary

Second, type and duration of treatment varied across studies, and more research is needed to refine the best regimen, dose and duration