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The most commonly used marker compounds used clinically are the carbohydrates mannitol and lactulose

The Forbes BIAcore characterization study reported that LR3 binds IGFBPs with the lowest affinity of the IGF analogs studied, with a corresponding ~3-fold increase in apparent in vitro potency [3]

The way to minimize the side effects is the slow initiation of drug therapy and the serial monitoring of specific laboratory tests

Yuan R, Tao X, Liang S, Pan Y, He L, Sun J, et al

the gene CAP1 , which codes for a bZip transcription factor of the AP-1 family, drives transcriptional responses to oxidative stress [55,56,57]

doi: 10.1001/jama.292.5.619