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In NOD mice, it delayed T1D onset, reduced insulitis, inhibited the expansion of T-BET+ CTLs, and promoted a T cell exhausted signature in the spleen and pancreatic lymph nodes (122, 123)

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Holocarboxylase Synthetase Deficiency Deficiency in holocarboxylase synthetase is an autosomal recessive disorder that results in multiple carboxylase deficiency