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Moreover, our study provides a mechanistic framework that could potentially explain other opioid-related side effects beyond constipation that may arise through modulation of central autonomic pathways (e.g., nausea, urinary retention, pruritus, and respiratory suppression) 41,42,43

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23 Total concentration of mercury, arsenic and selenium analysis Breast milk samples were transferred into Teflon vessels and digested with 70% nitric acid (HNO 3 ) and 30 % hydrogen peroxide (H 2 O 2 ) in a microwave oven (Mars 5x, CEM, Matthew, NC, USA)