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The chemical biology of ferroptosis in the central nervous system

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The drugs, including semaglutide (Ozempic, Wegovy and Rybelsus), tirzepatide (Mounjaro and Zepbound) and retatrutide (still in clinical trials), are used to treat both diabetes and obesity

Although the role of CD44 in the transport activity of xCT has not been validated so far, an interesting implication in iron endocytosis via CD44-bound hyaluronates is proposed (15) (Figure 1)

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At the 1mg dose, roughly 14% of participants reported nausea