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For example, in fish GPX4 activity contributes to a greater extent to total GPX activity, [19] GPX4a is the most highly expressed selenoprotein mRNA (in contrast to mammals where it is GPX1 mRNA) [20] and GPX4a appears to be highly inducible to changes within the cellular environment, such as changes in methylmercury and selenium status

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Additional proposed mechanisms include interaction with NMDA receptors and modulation of the stress and HPA axis , the hypothalamic-pituitary-adrenal system that governs the body's stress response

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Cancer Genomics Proteomics 21, 305315

[DOI] [PubMed] [Google Scholar] 131.Aguiar-Oliveira MH, and Salvatori R