Heller, D.A
Benzodiazepines and Other CNS Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants, such as benzodiazepines and other sedative hypnotics, anxiolytics, and tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), and other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death
No randomized controlled trial has ever evaluated phentermine plus tirzepatide for safety or efficacy
ROS-mediated inflammasome activation could explain the increased prevalence of IL-1 found in epilepsy as described above, which may in turn perpetuate cycle of oxidative stress and neuroinflammation
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