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As mentioned above, the link between TNF- and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30

Testosterone upregulates the expression of mitochondrial ND1 and ND4 and alleviates the oxidative damage to the nigrostriatal dopaminergic system in orchiectomized rats