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doi: 10.1126/sciadv.ado0016 249 ZhouZ.YangM.FangH.ZhangB.MaY.LiY.et al

GSH is synthesized in two steps, both ATP-dependent processes, catalyzed by the enzymes GCL (glutamate-cysteine ligase, aka -glutamylcysteine synthetase) and glutathione synthetase, and is regenerated by six enzyme-catalyzed reactions, known as the -glutamyl cycle

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These results indicate that NP4 are able to fully penetrate the three-dimensional cellular structure and generate a cytotoxic effect in multicellular tumor spheroids

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