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References PubMed The antioxidant glutathione: protective roles, cofactor functions, and regeneration mechanisms PubMed Glutathione and glutathione-dependent enzymes: coordinated defense against oxidative stress PMC Glutathione: roles in immune function, detoxification, and clinical applications PubMed The interplay of glutathione-related processes in antioxidant defense PMC Exploring safety and efficacy of glutathione supplementation: narrative review PubMed Glutathione as a skin-lightening agent and in melasma: systematic review PMC Glutathione: pharmacological aspects and implications for clinical use in NAFLD PubMed Oxidative stress: role of mitochondria and protection by glutathione PMC Efficacy of glutathione for NAFLD treatment: open-label pilot study PMC Protective effect of glutathione against oxidative stress-induced cytotoxicity via Nrf2/HO-1 pathway PubMed Glutathione in the treatment of liver diseases: clinical practice insights Nature Glutathione system enhancement for cardiac protection against oxidative stress PubMed Clinical effect of glutathione on skin color and related conditions: systematic review PMC Glutathione and its antiaging and antimelanogenic effects: RCT at 250 mg/day PubMed Oxidative stress and regulation of glutathione in lung inflammation PMC Subcutaneous drug injection review: pharmacologic considerations CDC Vaccine administration: subcutaneous route (angle/site

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[DOI] [PubMed] [Google Scholar] 176.Yang Z., Dolber P.C., Fraser M.O

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Zhao X, Kong D, Zhou Q et al (2021) Baicalein alleviates depression-like behavior in rotenone- induced Parkinsons disease model in mice through activating the BDNF/TrkB/CREB pathway

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doi: 10.1016/J.ADVNUT.2023.03.015 27

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Importantly, PRKAA1 knockdown increased while ectopic AMPK1 expression reduced the sensitivity of Huh7 cells to combination treatment (Extended Data Fig

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