A local reduction in cortical GABAergic synapses after a loss of endogenous brain-derived neurotrophic factor, as revealed by single-cell gene knock-out method
Statistical significance assessed by one-way ANOVA with Tukeys multiple comparisons test in a - c , e - j
Signals from the lysosome: a control Centre for cellular clearance and energy metabolism
Previous studies have shown that increased levels of anti-neutrophil cytoplasmic antibodies (ANCAs) in SLE patients serum suggest an impaired clearance mechanism for neutrophil debris, a significant source of self-antigens ( Apoptotic cell bodies: Lymphocytes from SLE patients frequently experience accelerated apoptosis, releasing nuclear antigens like nucleosomes into the extracellular space, which can then trigger immune responses and autoantibody formation ( Type-I IFN: Type-I IFN facilitates dendritic cell (DC) maturation, enhances autoimmune T cell survival, and activates autoantibody-producing B cells, primarily through sustained IFN- production, autophosphorylation, and activation of the IFN- receptor (IFNAR)-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) (92)
Mitocytosis, a migrasome-mediated mitochondrial quality-control process
Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity
