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Acknowledgments We thank the UK Biobank study, and the summary statistics data of UKB can be download from Neale lab ( and other GWAS summary-level data, which have been downloaded from We also thank all the reviewers and editors for their useful suggestions for improving this study

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Studies show that chronic stress, anxiety, and depression can cause your NAD+ levels in your body to prematurely deplete, causing sleep disturbances, cognitive impairments, and worsening mood problems