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The reduction in hepatic GSH after a therapeutic dose is minor, but a 15 g dose almost completely depletes hepatic GSH between 2 and 10 hours

Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGF/SMAD pathway

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Rare but more serious risks include infection at the IV site, vein irritation (phlebitis), electrolyte imbalance (with high-dose formulations), or allergic reaction