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A prodrug is a biologically inactive or less active compound that is metabolized in the body into a pharmacologically active form

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4.2.1 Effects on cellular-biochemistry 4.2.1.1 Nucleic acids Compared to nuclear DNA, the lack of protective histone proteins and their location in the vicinity of ROS production sites made organellar DNA more prone to be oxidatively damaged due to ROS-induced destruction in the affected cell

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