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However, many phase I products are not eliminated rapidly and undergo a subsequent reaction in which an endogenous substrate such as glucuronic acid, sulfuric acid, acetic acid, or an amino acid combines with the newly incorporated functional group to form a highly polar conjugate

In vivo results revealed that Jug-PLGA-NPs attracted melanoma cells with effective penetration and targeting properties and showed acceptable biocompatibility

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Meloni AR, DeYoung MB, Lowe C, Parkes DG

Mol Plant-Microbe Interact 26:100312