To confirm the binding mode between c-MET II and HGF I as shown in our structure, we introduced three point mutations in the K1 domain of HGF, including E159R, E195R, and R197E, to disrupt this interface, and examined the effects of these mutations on c-MET activation
Do not double up on doses to make up for a missed one, as this could increase the risk of potential side effects
The most commonly reported side effects in clinical trials include: Nausea Vomiting Diarrhea Constipation Most of these symptoms were mild to moderate and tended to improve over time as the body adjusted to the medication, especially when doses were increased gradually
Cushing's syndrome: Update on signs, symptoms and biochemical screening
PMID: 24 SanoTBakerDViragTWadaAYatomiYKobayashiTet al
10.1016/S0021-9673(99)00902-4 J