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This systemic mechanism is part of why TB-500 is sometimes considered for injuries that involve more diffuse tissue involvement or chronic, widespread inflammation rather than a single discrete injury site

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Annals of Clinical and Laboratory Science, 45(4), 426432

In one small case series, higher combined doses (4 mg BPC-157 + 6 mg TB-500 administered intra-articularly) showed better results compared to lower-dose approaches