Polyphenols appear to be effective chemopreventive drugs due to a number of protective actions they exhibit, including cell cycle signaling modification, activation of antioxidant enzymes, apoptosis, and cell cycle arrest
SG-55 is a selective, noncompetitive and orally active AKR1C3 inhibitor with an IC 50 of 5 nM and a K i of 10 nM
As such, this amino acid molecule is more resistant to in vivo interactions compared to cysteine on its own
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All homogenates were frozen in liquid nitrogen and stored at 80 C until biochemical analyses