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The concept reframes exercise adaptation at a molecular level: part of what makes vigorous movement so beneficial may be the peptides it causes the mitochondria to secrete

A.Salto-TellezM.Laurent-PuigP.BardelliA.RolfoC.TaberneroJ.et al (2017)

Copper and zinc levels checked every 12 weeks can confirm that neither mineral is drifting outside healthy ranges

The copper stays local, the bioavailability jumps, and you sidestep the systemic question

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Instead, it may be that chronic diseases cause low glutathione levels, which then can exacerbate the conditions due to an inability to counteract the increasing levels of oxidative stress