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GPx1 (/) mouse fibroblasts showed a decrease in protein kinase B (Akt) phosphorylation at Ser-473 during stimulation with hydrogen peroxide, while GPx1-under-expressed MCF-7 cells did not affect the expression and phosphorylation of p38 MAPK [52]

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Graphs plotting and IC 50 , EC 50 , EFFECTMAX calculations were carried out in the bell-shape module (nonlinear regression) of GraphPad Prism v.7.0 (GraphPad Software Inc.) for cell viability assays data

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10.1016/j.tox.2024.154030 419 SunJ.XuJ.LingY.WangF.GongT.YangC.et al