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Bristol Myers Squibbs Sotyktu (deucravacitinib), one of several treatments for psoriasis approved in 2022, is the first drug to include deuterium from its inception

Duncan, A., Yacoubian, C., Watson, N., & Morrison, I

E4), ERK 1:1000 (137F5), KRAS 1:1000 (E2M9G), KRASG12D 1:1000 (D8H7), KRT81 1:1000 (H00003887-M01J), ZEB1 1:1000 (D80D3), E-Cadherin 1:1000 (24E10), N-Cadherin 1:1000 (D4R1H), Vimentin 1:1000 (D21H3), GATA-6 1:1000 (D61E4), SLUG 1:1000 (C19G7), SNAIL 1:1000 (C15D3), GPX4 1:1000 (E5Y8K) and Actin 1:5000 (A2066)

This cascade of mitochondrial damage, along with the impaired ability of mitochondria to regulate calcium homeostasis and bioenergetics, leads to further neuronal injury and death [157]

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Use of stomach acid-resistant capsules (DRcaps ) further protect stability