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A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604, particularly combined with hyaluronic acid, improved cartilage integrity and reduced joint degradation

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Confirmed at 28 days A follow-up 28-day study (Babula et al., 2024) extended the finding: 5-Amino-1MQ dose-dependently limited body weight and fat mass gain without changing food intake, and it improved liver markers in obese mice

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