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The absorption of vitamin B12 is fraught with hurdles: In the stomach, vitamin B12 needs to bind with a protein called Intrinsic Factor to absorb, plus sufficient acid to release it from protein foods

In many cases, individuals may transition to a maintenance phase where injections are administered less frequently, such as once every two weeks or once a month

After a B12 shot, blood levels rise well above the desired range (150-700 pmol/L in most places), and stay high for a while

doi:10.3390/nu11030557

These findings align with earlier research showing that combining HA with GH enhances cartilage repair more effectively than HA alone [1]

The absorption process is highly efficient at physiological doses, with approximately 50% of dietary B12 absorbed when consuming around 1 microgram