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Nearly everything known comes from animal studies, so the human picture is still thin

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While mice lacking adipose HSL can achieve near normal rates of TAG hydrolysis, these animals display severely blunted DAG lipase activity, and as a result, DAG accumulates in adipose tissues (44)

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In addition, B12 deficiency can result in Megaloblastic Anemia, a type of anemia in which the red blood cells grow without dividing, becoming enlarged

While it's broadly deemed safe, some users may experience gastrointestinal upsets, occasional headaches, or skin irritations