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Neuronal mitochondrial dysfunction and central hypometabolism not only impair synaptic plasticity in cognitive-related brain regions but also further promote the release of neuronal DAMPs (e.g., mtDNA), which can activate local microglia in the central nervous system, forming a central energy-inflammation positive feedback loop

Blots were imaged with a ChemiDoc MP Imaging system (Bio-Rad)

21, 23 Consider supplementation when the patient is prescribed medications causing folate deficiency, e.g., methotrexate

The six common reasons 1

Cancer Biology & Therapy , 12 (4), 253259

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