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It is therefore proposed that the C* domain located at the C-terminus of CesA and the TE domain located at the C-terminus of CesB function as a cooperative esterification and depsipeptide elongation center ( DP4 DP8 DP12 ), repeatedly recruiting the action of the C* domain prior to macrocyclization by the TE domain

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Similar to insulin, there are human-created, synthetic peptides that can be used to treat certain deficiencies or medical conditions

1987 Jun-Sep;23(4):195-200

- Chang et al