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In elderly patients with depression, a recent cross-sectional study revealed that reduced abundance of Akkermansia in the gut microbiota leads to increased levels of free fatty acids (FFA), contributing to cognitive decline (170) ( Figure 1A )

Its copper-binding capacity contributes to enzymatic balance critical for follicular metabolism

Similarly, a role for NO as an antioxidant during heavy metal mediated toxicity has been highlighted recently by Saxena and Shekhawat (2013)

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By increasing the amount of fat burned during exercise, it can help delay fatigue and improve endurance

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