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A reducing milieu renders cofilin insensitive to phosphatidylinositol 4,5-bisphosphate (PIP2) inhibition

While GS livers can be used for transplantation, there is a risk of post-transplant hyperbilirubinemia when the donor liver carries the GS genotype[45]

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By utilizing NADPH, FSP1 reduces coenzyme Q to ubiquinol, effectively halting lipid autoxidation ( Figure 1 ) (60, 61)

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By restoring depleted antioxidant stores, it supports mitochondrial function, protects tissues, and reinforces the body's natural ability to repair, regenerate, and stay youthfully active