is tobacco substance abuse Addiction Guide: Symptoms, Risks & Recovery Substance Prevention Through Safe Practices

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10.1080/10550490601006055 [DOI] [PMC free article] [PubMed] [Google Scholar] East KA, Reid JL, Rynard VL, & Hammond D (2021)

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"We identified a novel circuit in the brain that becomes active during nicotine withdrawal, specifically increasing anxiety." Tapper and researchers from the Scripps Research Institute in California have conducted experiments over several years examining a region of the brain called the interpeduncular nucleus, which has previously been linked to withdrawal symptoms