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In contrast, drug dependence is primarily identified by tolerance and withdrawal symptoms, where individuals need larger amounts of a drug to achieve the same effect and experience physical symptoms when drug use is reduced or stopped

LD50 values) have considerable uncertainty (for example, more than a factor of 10 for diazepam in different species)

Kunz D, Schmitz S, Mahlberg R, Mohr A, Stter C, Wolf KJ, Herrmann WM (1999)

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Conclusions Young adult bar patrons consistently reported a high smoking rate and a strong relationship between smoking and drinking, regardless of the different bar cultures and tobacco control contexts in each of the three cities