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Indeed, although many studies have clearly shown that several interventions including pharmacological therapy and lifestyle modifications improve endothelial function under the condition of relatively mild vascular endothelial dysfunction [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35], we have shown that advanced endothelial dysfunction is not reversible even by appropriate pharmacological therapy [94]

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Research suggests that frequent adolescent use is associated with lasting changes in brain development that may contribute to difficulties with information processing, memory, attention, and other cognitive functions later in life

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We adjust the plan extra protective medications, closer follow-up, ulcer screening

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