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46 In 2019, Nordic Cochrane Centre investigators reanalyzed a highly cited network meta-analysis of 522 antidepressant trials (N=116,477 patients) published in 2018

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Antidepressants: SSRIs and Tricyclics SSRIs such as fluoxetine and sertraline, along with older tricyclic antidepressants, treat depression and anxiety by adjusting the brains serotonin signalling