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PubMed and Scopus databases were searched in April 2024 using the search terms: (never-smokers OR never smokers OR never smok* OR nive OR healthy) AND (e-cig* OR e-cigarette OR ENDS OR electronic cigarette*) AND (respir* OR lung) AND (cohort or observational or follow-up OR randomized controlled trial OR RCT)

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Smoking starves the body of Vitamin C a key component in the manufacturing of collagen and interferes with the production of an enzyme called matrix metalloproteinase that regulates collagen production, which leads to skin that is lined and gaunt

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