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This shift explains why many long-term smokers end up with higher central adiposity compared to non-smokerseven when their overall weight seems stable

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While some of the discrepancies in these results may be from our definition of M1 vs M2, which is a reductive approach to macrophage phenotyping, it is also likely that differences in dose, duration, constituent chemicals and other aspects of e-cigarette delivery are responsible, as well as altered cellular responses in the setting of signaling from other cells in vivo

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