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The tax on little cigars will increase to $1.01 from 4 cents and the federal tax on pipe tobacco will increase 157 percent to $2.83 per pound from $1.10 per pound

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14 Nicotine undergoes additional metabolism through glucuronidation, catalyzed primarily by UGT2B10 15 to form nicotine glucuronide (Nic-Gluc) and oxygenation by flavin monooxygenases (FMOs) including FMO1 and FMO3 16 to form nicotine-N-oxide (NOX)