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The candidate genes that play a key role in nicotine addiction include those associated with the dopaminergic neurotransmitter system (e.g., DRD2, DRD3, DRD4), cellular transport system (e.g., SLC1A2, SLC6A4), serotonergic neurotransmitter system (e.g., HTR2A), nicotinic neurotransmitter system (e.g., CHRNA4, CHRNA5, CHRNA3, CHRNA7, CHRNB4), opioidergic activity (e.g., OPRM1), and nicotine metabolism (e.g., CYP2A6) ( Figure 1 nAChRs are primary targets of nicotine, nicotine exerts direct and indirect effects on other receptor systems (e.g., opioid, serotonergic, glutamatergic) that also mediate nicotine-induced behavioral and neural changes in humans

Retailers were given a 60-day grace period from May 1 (ending around June 29, 2025) to sell through or remove any existing inventory that is not on the approved list

This is also when cigars reached peak popularity and benefited from mass production and market demand

The Tobacco Company Restaurant is now a multifaceted dining and entertainment showplace

As a result, nicotine tolerance can develop

This way, consumers and policymakers can be misled about the health consequences of smoking or vaping 38