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[3] Betel nuts were introduced into Hunan, the biggest consumer of betel nuts, more than 300 years ago and embedded in the social culture of the region that they were listed as a provincial-level cultural heritage in 2016

Although serious CV events can occur without warning symptoms, patients should be alert for the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should ask for medical advice when observing any indicative sign or symptoms

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