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Cigarette smoke exacerbates TNBS-induced colitis but alleviates DSS-induced ulcerative colitis in C57BL/6JGpt-Tg (human GPR15 ) mice To further investigate the effects of GPR15 overexpression on smoking-related colitis, we induced acute colitis via TNBS and DSS in transgenic C57BL/6JGpt-Tg (human GPR15 ) mice and their littermate controls

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Cigarette smoke is considered one of the most powerful environmental modifiers of DNA methylation ( Figure 2 )

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2011a;29:117138