piece of tobacco Humans' Earliest Evidence Use Uncovered in Utah Tobacco Poisoning: Identifying It and

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Am J Transplant 10:24212430

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[244] Some long-term effects of nicotine may be irreversible because "it is entirely possible that doses of nicotine achieved in the brains of human smokers can damage or kill mHb [medial habenula] neurons that regulate nicotine avoidance behaviors", but more studies are needed to elucidate this underlying mechanism of nicotine-induced degeneration of the mHb-IPn circuit