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[52] Stem lettuce was first developed in China, where it remains primarily cultivated

In the United States, the FDA continues to regulate e-cigarette marketing and flavor authorization, restricting access to certain products and creating compliance challenges for manufacturers

[42] AEMSA guidelines recommend that the nicotine levels in e-liquids be within the amount of 10% from the levels stated on the label

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In addition to self-reported smoking status and CO measures taken at each visit, urinary anabasine and anatabine concentration will be used as the principle objective measure of the primary outcome (continuous abstinence from smoking during the last 4 weeks of treatment)