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The formation of 1 appears to be stereoselective, as the ( S ) 1 enantiomer makes up 96% of 1 formed in N

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Empirically, future research could incorporate measures of cessation timing and years since quitting, along with prior smoking duration and intensity, to further decompose the observed higher risk among former smokers into two mechanisms: cumulative exposure and disease-induced cessation

Simunkova, K., Hill, M