CONCLUSIONS Although the genetic markers did not contribute to smoking cessation treatment, we showed that starting smoking cessation treatment with the most effective drug, varenicline, and then adding bupropion at Week 4 for those who were not able to achieve smoking cessation by then, led to an excellent smoking cessation rate and reduced the chances of unnecessary drug administration and increased adverse events.
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The authors noted the exact mechanisms underlying liver cancer from smoking are complex, but they linked tobacco use with an elevated risk of liver cancer