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As the AHA points out, The data on health effects to date, studied primarily in healthy people with short-term exposure, reveal little or no evidence of severe adverse events

~ Linked to increased triglycerides and metabolic syndrome risk in animal and human studies

You will also see that some offer refillable tanks while some just offer pre-filled cartridges, when you are done you simply swap them out

Ethics statement The animal study was reviewed and approved by the Animal Care and Use Committee of Al-Zaytoonah University of Jordan

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However, the way that different countries regulate them, I think, conveys some of the uncertainty with what these products are and what they do