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The fact that numerous attempts in this direction have been made, and yet thee is no substitute for tobacco and no de-nicotinized tobacco in general use, is itself a sufficient answer to the question
As soon as I could afford to, I graduated to so-called king sized ones, and smoked a packet of 20 per day
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About GTRI The Georgia Tech Research Institute (GTRI) is the nonprofit, applied research division of the Georgia Institute of Technology (Georgia Tech)
Surgeon Generals report identified the reduction of nicotine content in cigarettes to non-addictive levels as one of several potential specific strategies to accelerate declines in combustible tobacco smoking and end the tobacco epidemic
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