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the penalty to the individual smoker is more indirect (were not physically stopping you from smoking, were just putting the burden of finding a location on you), while the benefit to everyone else in the now-smoke-free space is overwhelmingly clear

Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety

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It's not clear what causes throat cancer, but there are factors that can increase your risk