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on a per capita basis, sales have continued to decline over this time, as population grew from approximately 31 million in 2001 iv to nearly 37 million in 2021

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Previous studies have shown that colchicine in vivo and in vitro reduced the expression of IL-1, IL-6, IL-8, IL-18, TNF-, MCP-1, ICAM-1, VCAM-1, and E-selectin at mRNA and protein level [23,24,25,26,27]