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Furthermore, prolonged nAChR activation is linked to the onset and persistence of smoking and other addictive behaviors [69] with earlier beginning in children with ADHD [70]

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doi:10.1056/NEJMsa1405092 pmid:25184865 Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux JP (2001) Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei