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[15][22] Emergency responses for nicotine overdose Call 911 or the American Association of Poison Control Center at 1-800-222-1222 right away if any of the following symptoms occur : difficulty breathing, seizures or convulsions, loss of consciousness, irregular or slow heartbeat, severe vomiting or persistent nausea, confusion, dizziness, or altered mental state, excessive salivation (drooling) or sweating

The highest density of these receptors is located in the thalamus and substantia nigra

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